Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10939.149 | 0.9394 | 0.9268 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10939.149 | 0.9624 | 0.9547 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10939.149 | 0.9689 | 0.9627 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10939.149 | 0.9891 | 0.9869 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10939.149 | 0.9217 | 0.9049 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10939.149 | 0.9435 | 0.9317 | 1.6748 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12608.166 | 0.9905 | 0.9803 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12608.166 | 0.9842 | 0.9673 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12608.166 | 0.9732 | 0.9444 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12608.166 | 0.9616 | 0.9204 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12608.166 | 0.9782 | 0.9548 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12608.166 | 1.0375 | 1.0780 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 4 | uM | 12608.166 | 1.0332 | 1.0691 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 20 | uM | 12608.166 | 1.0507 | 1.1053 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 100 | uM | 12608.166 | 0.8913 | 0.7748 | 0.9629 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10580.137 | 0.9447 | 0.8711 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10580.137 | 0.9146 | 0.8014 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10580.137 | 0.9834 | 0.9613 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10580.137 | 0.9690 | 0.9276 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10580.137 | 0.9868 | 0.9690 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10580.137 | 0.9088 | 0.7880 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10580.137 | 0.9313 | 0.8400 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10580.137 | 0.9166 | 0.8059 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10580.137 | 0.8254 | 0.5974 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10754.149 | 0.9176 | 0.8768 | 1.3535 |