Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11850.161 | 0.9335 | 0.9347 | 2.0754 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11850.161 | 0.9133 | 0.9145 | 2.0754 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 4 | uM | 11850.161 | 0.8999 | 0.9009 | 2.0754 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 20 | uM | 11850.161 | 0.8142 | 0.8114 | 2.0754 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 100 | uM | 11850.161 | 0.4680 | 0.3872 | 2.0754 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10873.149 | 0.9719 | 0.9552 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10873.149 | 0.9800 | 0.9681 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10873.149 | 0.9875 | 0.9801 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10873.149 | 0.9600 | 0.9361 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10873.149 | 0.9406 | 0.9048 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10873.149 | 0.9760 | 0.9616 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10873.149 | 1.0097 | 1.0155 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10873.149 | 0.9430 | 0.9087 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10873.149 | 0.8565 | 0.7679 | 1.2562 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12400.166 | 0.9527 | 0.9311 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12400.166 | 0.9541 | 0.9332 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12400.166 | 0.9798 | 0.9707 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12400.166 | 0.9444 | 0.9190 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12400.166 | 0.9990 | 0.9985 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12400.166 | 0.9724 | 0.9600 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 4 | uM | 12400.166 | 0.9795 | 0.9702 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 20 | uM | 12400.166 | 0.9196 | 0.8823 | 1.3827 | |
| HCC70 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 100 | uM | 12400.166 | 0.6217 | 0.4182 | 1.3827 | |
| Hs 578T | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10694.149 | 0.9916 | 0.9928 | 2.3563 | |
| Hs 578T | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10694.149 | 0.9958 | 0.9965 | 2.3563 |