Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 4 | uM | 11854.161 | 1.0042 | 1.0069 | 1.2085 | |
| BT-20 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 20 | uM | 11854.161 | 0.8821 | 0.8029 | 1.2085 | |
| BT-20 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 100 | uM | 11854.161 | 0.7058 | 0.4990 | 1.2085 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12056.161 | 0.9194 | 0.8277 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12056.161 | 0.9107 | 0.8091 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12056.161 | 0.9190 | 0.8268 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12056.161 | 0.9391 | 0.8695 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12056.161 | 0.9714 | 0.9387 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12056.161 | 0.9706 | 0.9370 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12056.161 | 0.9881 | 0.9745 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12056.161 | 0.7854 | 0.5435 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12056.161 | 0.5129 | -0.0228 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12178.161 | 1.0197 | 1.0693 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12178.161 | 0.9751 | 0.9139 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12178.161 | 0.9324 | 0.7696 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12178.161 | 0.9867 | 0.9537 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12178.161 | 1.0034 | 1.0118 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12178.161 | 0.9722 | 0.9040 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12178.161 | 1.0504 | 1.1794 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12178.161 | 0.8737 | 0.5794 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12178.161 | 0.6568 | -0.0407 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12291.166 | 0.9446 | 0.8176 | 0.5962 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12291.166 | 0.8835 | 0.6249 | 0.5962 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12291.166 | 0.9599 | 0.8672 | 0.5962 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12291.166 | 0.8505 | 0.5244 | 0.5962 |