Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10518.137 | 0.8429 | 0.7425 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10518.137 | 0.6624 | 0.4349 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10753.149 | 0.9360 | 0.9088 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10753.149 | 0.9708 | 0.9586 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10753.149 | 0.9804 | 0.9722 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10753.149 | 0.9815 | 0.9738 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10753.149 | 0.9972 | 0.9960 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10753.149 | 0.9307 | 0.9012 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10753.149 | 0.9658 | 0.9515 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10753.149 | 0.9202 | 0.8860 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10753.149 | 0.7379 | 0.6138 | 1.4167 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12000.166 | 0.9353 | 0.8285 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12000.166 | 0.9154 | 0.7767 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12000.166 | 0.9867 | 0.9645 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12000.166 | 0.9221 | 0.7941 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12000.166 | 0.9514 | 0.8708 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12000.166 | 0.9002 | 0.7374 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 4 | uM | 12000.166 | 0.8925 | 0.7176 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 20 | uM | 12000.166 | 0.8168 | 0.5253 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 100 | uM | 12000.166 | 0.5546 | -0.0917 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12084.161 | 0.8805 | 0.8319 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12084.161 | 0.8951 | 0.8527 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12084.161 | 0.9018 | 0.8623 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12084.161 | 0.9143 | 0.8801 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12084.161 | 0.9849 | 0.9792 | 1.4492 |