Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12084.161 | 0.9346 | 0.9087 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 4 | uM | 12084.161 | 0.9226 | 0.8919 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 20 | uM | 12084.161 | 0.8208 | 0.7452 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 100 | uM | 12084.161 | 0.5512 | 0.3259 | 1.4492 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12001.166 | 0.9088 | 0.6841 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12001.166 | 0.8924 | 0.6298 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12001.166 | 0.9447 | 0.8055 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12001.166 | 0.8839 | 0.6021 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12001.166 | 0.9305 | 0.7572 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12001.166 | 0.8822 | 0.5967 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12001.166 | 0.8695 | 0.5555 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12001.166 | 0.8465 | 0.4824 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12001.166 | 0.6934 | 0.0357 | 0.5565 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10693.149 | 1.0079 | 1.0181 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10693.149 | 1.0026 | 1.0060 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10693.149 | 1.0241 | 1.0553 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10693.149 | 1.0086 | 1.0199 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10693.149 | 1.0128 | 1.0294 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10693.149 | 0.9832 | 0.9616 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10693.149 | 1.0053 | 1.0123 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10693.149 | 0.9863 | 0.9686 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10693.149 | 0.9664 | 0.9231 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 11936.161 | 1.0353 | 1.0959 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 11936.161 | 0.9470 | 0.8582 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 11936.161 | 0.9727 | 0.9266 | 0.7410 |