Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12070.161 | 0.8894 | 0.8263 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12070.161 | 0.8911 | 0.8290 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12070.161 | 0.9080 | 0.8559 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12070.161 | 0.9626 | 0.9419 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12070.161 | 0.9546 | 0.9293 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12070.161 | 0.9962 | 0.9941 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12070.161 | 0.9961 | 0.9940 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12070.161 | 0.8859 | 0.8208 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12070.161 | 0.9289 | 0.8889 | 1.2903 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12112.161 | 0.9396 | 0.9288 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12112.161 | 0.9493 | 0.9403 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12112.161 | 0.9668 | 0.9611 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12112.161 | 0.9171 | 0.9017 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12112.161 | 0.9707 | 0.9657 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12112.161 | 0.8754 | 0.8509 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 4 | uM | 12112.161 | 1.0233 | 1.0270 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 20 | uM | 12112.161 | 0.8267 | 0.7903 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 100 | uM | 12112.161 | 0.6004 | 0.4862 | 1.7182 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10518.137 | 0.8882 | 0.8177 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10518.137 | 0.9396 | 0.9020 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10518.137 | 0.9248 | 0.8779 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10518.137 | 0.9932 | 0.9890 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10518.137 | 1.0795 | 1.1272 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10518.137 | 0.9381 | 0.8996 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10518.137 | 0.9629 | 0.9400 | 1.2405 |