Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12305.166 | 0.9152 | 0.9409 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12305.166 | 0.8921 | 0.9242 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12305.166 | 0.9700 | 0.9795 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12305.166 | 0.9067 | 0.9348 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 4 | uM | 12305.166 | 0.8546 | 0.8964 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 20 | uM | 12305.166 | 0.7777 | 0.8369 | 2.9556 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 100 | uM | 12305.166 | 0.6466 | 0.7257 | 2.9556 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10473.137 | 0.9292 | 0.8745 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10473.137 | 0.9220 | 0.8615 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10473.137 | 0.9514 | 0.9139 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10473.137 | 1.0204 | 1.0359 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10473.137 | 1.0050 | 1.0088 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10473.137 | 1.0251 | 1.0443 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10473.137 | 0.9729 | 0.9521 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10473.137 | 0.9910 | 0.9840 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10473.137 | 1.0465 | 1.0819 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10755.149 | 0.9073 | 0.8090 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10755.149 | 0.7032 | 0.3906 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10755.149 | 0.9532 | 0.9035 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10755.149 | 0.9500 | 0.8969 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10755.149 | 0.9441 | 0.8847 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10755.149 | 0.9472 | 0.8912 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10755.149 | 0.9702 | 0.9385 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10755.149 | 0.9480 | 0.8927 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10755.149 | 0.9953 | 0.9902 | 0.9687 |