Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 0.267 | uM | 9860.019 | 0.8682 | 0.8399 | 1.6927 | |
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 1.33 | uM | 9860.019 | 0.8199 | 0.7786 | 1.6927 | |
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 6.67 | uM | 9860.019 | 0.6887 | 0.6045 | 1.6927 | |
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 33.3 | uM | 9860.019 | 0.0556 | -0.6371 | 1.6927 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7538.016 | 0.9491 | 0.9057 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7538.016 | 0.8554 | 0.7312 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7538.016 | 0.6589 | 0.3604 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7538.016 | 0.8091 | 0.6446 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7538.016 | 0.7029 | 0.4440 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7538.016 | 0.7500 | 0.5332 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7538.016 | 0.9753 | 0.9544 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7538.016 | 0.7245 | 0.4851 | 1.0824 | |
| SUM44PE | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7538.016 | 0.5180 | 0.0892 | 1.0824 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7540.016 | 0.9040 | 0.7975 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7540.016 | 0.9618 | 0.9193 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7540.016 | 0.9086 | 0.8072 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7540.016 | 0.9657 | 0.9276 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7540.016 | 0.9740 | 0.9450 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7540.016 | 0.9595 | 0.9143 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7540.016 | 1.0539 | 1.1141 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7540.016 | 0.8762 | 0.7390 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7540.016 | 0.5635 | 0.0903 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7923.016 | 0.5727 | -0.1768 | 0.6280 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7923.016 | 0.5072 | -0.3214 | 0.6280 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7923.016 | 0.5252 | -0.2828 | 0.6280 |