Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 85.2 | uM | 9233.121 | 0.4970 | -0.0443 | 0.9468 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7812.047 | 0.9989 | 0.9979 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7812.047 | 1.0124 | 1.0230 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7812.047 | 1.0509 | 1.0943 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7812.047 | 0.9973 | 0.9950 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7812.047 | 1.0113 | 1.0209 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7812.047 | 0.9440 | 0.8959 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7812.047 | 0.9432 | 0.8944 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7812.047 | 1.0284 | 1.0527 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7812.047 | 0.7390 | 0.5106 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9244.034 | 1.1133 | 1.3720 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9244.034 | 1.0613 | 1.1984 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9244.034 | 1.0431 | 1.1388 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9244.034 | 1.0242 | 1.0774 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 9244.034 | 0.9167 | 0.7419 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 9244.034 | 0.9796 | 0.9355 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 9244.034 | 1.1826 | 1.6107 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 9244.034 | 1.0337 | 1.1080 | 0.6294 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 9244.034 | 0.3406 | -0.6387 | 0.6294 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7813.007 | 0.9546 | 0.8919 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7813.007 | 1.0461 | 1.1107 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7813.007 | 1.1301 | 1.3151 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7813.007 | 1.0895 | 1.2158 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7813.007 | 1.1518 | 1.3683 | 0.8361 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7813.007 | 0.5547 | -0.0116 | 0.8361 |