Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10816.153 | 1.0465 | 1.1216 | 0.7704 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10816.153 | 0.7025 | 0.2645 | 0.7704 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12319.165 | 0.8625 | 0.7005 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12319.165 | 0.8545 | 0.6831 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12319.165 | 0.9636 | 0.9203 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12319.165 | 0.8121 | 0.5919 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12319.165 | 0.7762 | 0.5148 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12319.165 | 1.2102 | 1.4655 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12319.165 | 0.9186 | 0.8222 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12319.165 | 0.9679 | 0.9296 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12319.165 | 0.6798 | 0.3097 | 0.9117 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12580.165 | 1.0030 | 1.0026 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12580.165 | 1.0146 | 1.0127 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12580.165 | 1.0211 | 1.0184 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12580.165 | 1.0362 | 1.0313 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12580.165 | 0.9593 | 0.9640 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.267 | uM | 12580.165 | 1.0215 | 1.0186 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 1.33 | uM | 12580.165 | 0.9445 | 0.9507 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 6.67 | uM | 12580.165 | 0.9789 | 0.9815 | 2.2883 | |
| MB 157 | Unknown | Unknown | AS-252424 | PI3K | PI3K | 33.3 | uM | 12580.165 | 1.0267 | 1.0232 | 2.2883 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11056.158 | 1.0713 | 1.0510 | 2.7355 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11056.158 | 1.1315 | 1.0924 | 2.7355 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11056.158 | 1.0090 | 1.0066 | 2.7355 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11056.158 | 1.1809 | 1.1254 | 2.7355 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.107 | uM | 11056.158 | 1.1058 | 1.0749 | 2.7355 |