Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7432.067 | 0.0468 | -0.8956 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7432.067 | 0.0462 | -0.8968 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7432.067 | 0.0470 | -0.8950 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7432.067 | 0.0374 | -0.9159 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7432.067 | 0.0003 | -0.9992 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7433.067 | 1.0526 | 1.1038 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7433.067 | 1.0510 | 1.1006 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7433.067 | 1.0055 | 1.0109 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7433.067 | 1.0354 | 1.0697 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7433.067 | 0.0439 | -0.9083 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7433.067 | 0.0483 | -0.8991 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7433.067 | 0.0520 | -0.8916 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7433.067 | 0.0860 | -0.8221 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7433.067 | 0.0030 | -0.9936 | 1.0142 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7435.067 | 1.0421 | 1.1100 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7435.067 | 0.9852 | 0.9615 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7435.067 | 1.0108 | 1.0281 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7435.067 | 0.8106 | 0.5221 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7435.067 | 0.3120 | -0.5603 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7435.067 | 0.3003 | -0.5815 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7435.067 | 0.2641 | -0.6459 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7435.067 | 0.0819 | -0.9227 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7435.067 | 0.0005 | -0.9999 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7436.067 | 1.0159 | 1.0247 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7436.067 | 0.9756 | 0.9618 | 1.2834 |