Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5912.067 | 0.1607 | -0.5794 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5912.067 | 0.0748 | -0.7810 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5912.067 | 0.0064 | -0.9731 | 1.1725 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7429.067 | 1.0127 | 1.0114 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7429.067 | 1.0281 | 1.0252 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7429.067 | 1.0395 | 1.0352 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7429.067 | 0.9797 | 0.9816 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7429.067 | 0.1579 | -0.1302 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.267 | uM | 7429.067 | 0.0898 | -0.3256 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 1.33 | uM | 7429.067 | 0.0941 | -0.3113 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 6.67 | uM | 7429.067 | 0.0561 | -0.4544 | 2.2169 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 33.3 | uM | 7429.067 | 0.0028 | -0.8592 | 2.2169 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7430.067 | 1.0508 | 1.0520 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7430.067 | 1.0191 | 1.0197 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7430.067 | 0.9960 | 0.9959 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7430.067 | 1.0591 | 1.0604 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7430.067 | 0.5702 | 0.4952 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7430.067 | 0.3510 | 0.1629 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7430.067 | 0.3976 | 0.2404 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7430.067 | 0.3184 | 0.1056 | 1.9308 | |
| HCC1143 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7430.067 | 0.0046 | -0.8774 | 1.9308 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7432.067 | 1.0458 | 1.0882 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7432.067 | 1.0907 | 1.1746 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7432.067 | 1.0027 | 1.0051 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7432.067 | 0.9949 | 0.9901 | 1.0373 |