Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10693.149 | 0.9854 | 0.9666 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10693.149 | 1.0220 | 1.0505 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10693.149 | 1.0123 | 1.0283 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10693.149 | 1.0108 | 1.0247 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10693.149 | 1.0186 | 1.0428 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10693.149 | 0.9147 | 0.8055 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10693.149 | 0.5882 | 0.0877 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 11936.161 | 0.9758 | 0.9349 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 11936.161 | 0.9503 | 0.8669 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 11936.161 | 1.0880 | 1.2412 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 11936.161 | 1.0120 | 1.0325 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 11936.161 | 0.9909 | 0.9755 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 11936.161 | 1.0767 | 1.2097 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 11936.161 | 0.9203 | 0.7880 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11936.161 | 0.8893 | 0.7072 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11936.161 | 0.2482 | -0.6949 | 0.7410 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10872.149 | 0.9640 | 0.9543 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10872.149 | 1.0017 | 1.0022 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10872.149 | 1.0113 | 1.0142 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10872.149 | 0.9607 | 0.9500 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10872.149 | 0.9357 | 0.9180 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10872.149 | 0.9629 | 0.9528 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10872.149 | 0.8817 | 0.8473 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10872.149 | 0.9380 | 0.9209 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10872.149 | 0.5801 | 0.4188 | 1.5861 |