Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7436.067 | 0.9968 | 0.9950 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7436.067 | 1.0233 | 1.0363 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7436.067 | 0.3294 | -0.1581 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7436.067 | 0.2905 | -0.2366 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7436.067 | 0.2593 | -0.3014 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7436.067 | 0.1224 | -0.6108 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7436.067 | 0.0044 | -0.9711 | 1.2834 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7437.067 | 1.0782 | 1.4099 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7437.067 | 1.0624 | 1.3232 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7437.067 | 1.0410 | 1.2091 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7437.067 | 1.0285 | 1.1440 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7437.067 | 0.9519 | 0.7700 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7437.067 | 0.9200 | 0.6270 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7437.067 | 0.9428 | 0.7285 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7437.067 | 0.9140 | 0.6008 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7437.067 | 0.0078 | -1.0000 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7440.067 | 1.0271 | 1.1579 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7440.067 | 0.9921 | 0.9556 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7440.067 | 1.0233 | 1.1350 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7440.067 | 1.0433 | 1.2563 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7440.067 | 0.9111 | 0.5350 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7440.067 | 0.8796 | 0.3888 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7440.067 | 0.9004 | 0.4843 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7440.067 | 0.8687 | 0.3405 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7440.067 | 0.0103 | -1.0000 | 0.3519 |