Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10880.151 | 0.9278 | 0.9207 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10880.151 | 0.9899 | 0.9891 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10880.151 | 0.9806 | 0.9789 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10880.151 | 0.9526 | 0.9483 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10880.151 | 0.9175 | 0.9091 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10880.151 | 0.7660 | 0.7318 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10880.151 | 0.5560 | 0.4564 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10880.151 | 0.4517 | 0.3018 | 1.8509 | |
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10880.151 | 0.4309 | 0.2691 | 1.8509 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10581.139 | 0.8973 | 0.8199 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10581.139 | 0.9341 | 0.8848 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10581.139 | 0.9400 | 0.8952 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10581.139 | 0.9400 | 0.8951 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10581.139 | 0.9370 | 0.8899 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10581.139 | 0.8758 | 0.7819 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10581.139 | 0.8435 | 0.7245 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10581.139 | 0.7595 | 0.5741 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10581.139 | 0.8327 | 0.7054 | 1.1488 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11854.157 | 0.8941 | 0.8544 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11854.157 | 0.9110 | 0.8780 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11854.157 | 0.9023 | 0.8658 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11854.157 | 0.9085 | 0.8745 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11854.157 | 0.9288 | 0.9027 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11854.157 | 0.8892 | 0.8475 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 11854.157 | 0.8354 | 0.7712 | 1.4808 |