Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 11854.157 | 0.7835 | 0.6961 | 1.4808 | |
| BT-20 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 11854.157 | 0.8308 | 0.7647 | 1.4808 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12056.157 | 0.9628 | 0.9238 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12056.157 | 0.9647 | 0.9276 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12056.157 | 0.9941 | 0.9879 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12056.157 | 0.9518 | 0.9012 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12056.157 | 1.0131 | 1.0268 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12056.157 | 0.9144 | 0.8245 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12056.157 | 1.0272 | 1.0559 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12056.157 | 0.9473 | 0.8919 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12056.157 | 0.9264 | 0.8491 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12178.157 | 1.0432 | 1.1589 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12178.157 | 1.0325 | 1.1193 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12178.157 | 1.0045 | 1.0163 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12178.157 | 1.0466 | 1.1716 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12178.157 | 1.0195 | 1.0709 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12178.157 | 1.0340 | 1.1246 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12178.157 | 1.1631 | 1.6288 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12178.157 | 0.9639 | 0.8714 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12178.157 | 1.0873 | 1.3269 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12291.157 | 0.9758 | 0.9074 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12291.157 | 0.9906 | 0.9638 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12291.157 | 0.9472 | 0.8005 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12291.157 | 0.9280 | 0.7305 | 0.5161 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12291.157 | 1.0178 | 1.0696 | 0.5161 |