Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 2.4 | uM | 11660.143 | 0.9555 | 0.9143 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 12 | uM | 11660.143 | 0.9527 | 0.9088 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 60 | uM | 11660.143 | 0.7640 | 0.5436 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 300 | uM | 11660.143 | 0.4420 | -0.0887 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 1500 | uM | 11660.143 | 0.3954 | -0.1812 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 0.00384 | uM | 12003.143 | 0.9659 | 0.9452 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 0.0192 | uM | 12003.143 | 0.9028 | 0.8430 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 0.096 | uM | 12003.143 | 1.0016 | 1.0026 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 0.48 | uM | 12003.143 | 0.8778 | 0.8019 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 2.4 | uM | 12003.143 | 0.8310 | 0.7247 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 12 | uM | 12003.143 | 0.9268 | 0.8819 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 60 | uM | 12003.143 | 0.7491 | 0.5872 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 300 | uM | 12003.143 | 0.3753 | -0.0870 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 1500 | uM | 12003.143 | 0.3668 | -0.1035 | 1.2499 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 0.00384 | uM | 11939.143 | 0.9540 | 0.9466 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 0.0192 | uM | 11939.143 | 0.9325 | 0.9213 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 0.096 | uM | 11939.143 | 1.0150 | 1.0171 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 0.48 | uM | 11939.143 | 1.0261 | 1.0298 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 2.4 | uM | 11939.143 | 0.9601 | 0.9537 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 12 | uM | 11939.143 | 0.9870 | 0.9851 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 60 | uM | 11939.143 | 0.8984 | 0.8807 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 300 | uM | 11939.143 | 0.4198 | 0.2149 | 1.7414 | ||
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 1500 | uM | 11939.143 | 0.4050 | 0.1901 | 1.7414 | ||
| 184A1 | NM | Basal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12509.157 | 1.0093 | 1.0145 | 1.2837 | |
| 184A1 | NM | Basal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12509.157 | 0.9989 | 0.9983 | 1.2837 |