Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7892.001 | 0.9459 | 0.9582 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7892.001 | 0.4919 | 0.5273 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7892.001 | 0.3194 | 0.2962 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7892.001 | 0.3017 | 0.2684 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7892.001 | 0.3330 | 0.3168 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7892.001 | 0.1240 | -0.0952 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7893.001 | 0.9434 | 0.9500 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7893.001 | 0.9986 | 0.9988 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7893.001 | 0.9610 | 0.9657 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7893.001 | 0.9718 | 0.9753 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7893.001 | 0.5602 | 0.5554 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7893.001 | 0.4182 | 0.3701 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7893.001 | 0.3889 | 0.3275 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7893.001 | 0.4170 | 0.3683 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7893.001 | 0.2085 | 0.0130 | 2.3044 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7894.001 | 1.0496 | 1.1301 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7894.001 | 1.0115 | 1.0300 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7894.001 | 1.0563 | 1.1479 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7894.001 | 1.0273 | 1.0714 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7894.001 | 0.5191 | -0.1486 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7894.001 | 0.4046 | -0.3846 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7894.001 | 0.4555 | -0.2819 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7894.001 | 0.5093 | -0.1694 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7894.001 | 0.4283 | -0.3372 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7896.001 | 1.0081 | 1.0136 | 1.1912 |