Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7856.001 | 0.3063 | -0.6212 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7856.001 | 0.3286 | -0.5818 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7856.001 | 0.3292 | -0.5808 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7856.001 | 0.1905 | -0.8057 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7857.001 | 1.0478 | 1.0812 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7857.001 | 0.9524 | 0.9185 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7857.001 | 1.0414 | 1.0703 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7857.001 | 0.9905 | 0.9838 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7857.001 | 0.3712 | -0.1411 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7857.001 | 0.2256 | -0.4383 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7857.001 | 0.2105 | -0.4707 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7857.001 | 0.2129 | -0.4654 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7857.001 | 0.1337 | -0.6406 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9501.001 | 1.0544 | 1.1092 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9501.001 | 1.0540 | 1.1084 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9501.001 | 1.1104 | 1.2216 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9501.001 | 0.9707 | 0.9411 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9501.001 | 0.3052 | -0.3919 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9501.001 | 0.3419 | -0.3184 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9501.001 | 0.3199 | -0.3625 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9501.001 | 0.2659 | -0.4703 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9501.001 | 0.2245 | -0.5531 | 0.9969 | |
| HMT-3522 S1 | Unknown | Unknown | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7911.001 | 0.9428 | 0.9042 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7911.001 | 1.0290 | 1.0483 | 1.2005 | |
| HMT-3522 S1 | Unknown | Unknown | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7911.001 | 1.0922 | 1.1524 | 1.2005 |