Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9258.001 | 0.2776 | -0.6681 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9258.001 | 0.2452 | -0.7209 | 0.7137 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7819.001 | 1.0227 | 1.0936 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7819.001 | 1.0409 | 1.1699 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7819.001 | 1.0254 | 1.1047 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7819.001 | 0.9065 | 0.6380 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7819.001 | 0.9035 | 0.6270 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7819.001 | 0.8520 | 0.4444 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7819.001 | 0.8918 | 0.5847 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7819.001 | 0.8336 | 0.3816 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7819.001 | 0.5439 | -0.4200 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7820.001 | 0.9563 | 0.8872 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7820.001 | 0.9566 | 0.8879 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7820.001 | 1.0366 | 1.0958 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7820.001 | 0.9124 | 0.7754 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7820.001 | 0.9621 | 0.9020 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7820.001 | 0.8146 | 0.5319 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7820.001 | 0.9003 | 0.7447 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7820.001 | 0.8218 | 0.5497 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7820.001 | 0.6119 | 0.0561 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7821.001 | 1.0127 | 1.0783 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7821.001 | 1.0133 | 1.0817 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7821.001 | 1.0352 | 1.2212 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7821.001 | 0.9847 | 0.9087 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7821.001 | 0.8888 | 0.3983 | 0.3296 |