Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7821.001 | 0.8898 | 0.4031 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7821.001 | 0.9547 | 0.7375 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7821.001 | 0.8765 | 0.3406 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7821.001 | 0.5605 | -0.6547 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9278.001 | 1.0587 | 1.2748 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9278.001 | 0.9749 | 0.8885 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9278.001 | 1.0128 | 1.0584 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9278.001 | 1.0286 | 1.1314 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9278.001 | 0.9067 | 0.6032 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9278.001 | 0.7895 | 0.1728 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9278.001 | 0.8138 | 0.2561 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9278.001 | 0.7651 | 0.0927 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9278.001 | 0.6268 | -0.3034 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10019.001 | 0.9491 | 0.7533 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10019.001 | 1.0440 | 1.2295 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10019.001 | 1.0110 | 1.0557 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10019.001 | 0.9662 | 0.8340 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10019.001 | 1.0046 | 1.0232 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10019.001 | 0.8985 | 0.5271 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10019.001 | 0.8651 | 0.3879 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10019.001 | 0.8575 | 0.3577 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10019.001 | 0.6192 | -0.4023 | 0.3968 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9294.001 | 0.9828 | 0.9564 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9294.001 | 0.9879 | 0.9692 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9294.001 | 1.0068 | 1.0174 | 0.7859 |