Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11851.157 | 0.9316 | 0.9059 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11851.157 | 0.9293 | 0.9028 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11851.157 | 0.7887 | 0.7019 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11851.157 | 0.6771 | 0.5342 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11851.157 | 0.7158 | 0.5933 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11851.157 | 0.5120 | 0.2687 | 1.4707 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10875.151 | 1.0192 | 1.0542 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10875.151 | 1.0126 | 1.0357 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10875.151 | 0.9711 | 0.9189 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10875.151 | 0.9638 | 0.8988 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10875.151 | 0.9362 | 0.8225 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10875.151 | 0.7519 | 0.3381 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10875.151 | 0.6228 | 0.0261 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10875.151 | 0.5970 | -0.0334 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10875.151 | 0.5442 | -0.1515 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12428.157 | 1.0080 | 1.0163 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12428.157 | 0.9954 | 0.9906 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12428.157 | 1.0007 | 1.0015 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12428.157 | 1.0042 | 1.0085 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12428.157 | 0.9740 | 0.9473 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12428.157 | 0.8215 | 0.6378 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 12428.157 | 0.7078 | 0.4077 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 12428.157 | 0.6439 | 0.2787 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 12428.157 | 0.6251 | 0.2408 | 0.9842 | |
| SUM149PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10819.151 | 0.9930 | 0.9934 | 2.1209 |