Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9294.001 | 1.0125 | 1.0319 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9294.001 | 0.8789 | 0.6970 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9294.001 | 0.8105 | 0.5309 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9294.001 | 0.7934 | 0.4897 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9294.001 | 0.7676 | 0.4285 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9294.001 | 0.3066 | -0.5557 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10031.001 | 1.0145 | 1.0323 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10031.001 | 0.9978 | 0.9950 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10031.001 | 1.0234 | 1.0521 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10031.001 | 0.9084 | 0.7972 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10031.001 | 0.9125 | 0.8062 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10031.001 | 0.8344 | 0.6349 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10031.001 | 0.9251 | 0.8340 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10031.001 | 0.8558 | 0.6815 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10031.001 | 0.2885 | -0.4989 | 0.8981 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7825.001 | 0.9319 | 0.9137 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7825.001 | 1.0203 | 1.0253 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7825.001 | 0.9413 | 0.9258 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7825.001 | 0.8856 | 0.8536 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7825.001 | 0.7921 | 0.7288 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7825.001 | 0.5258 | 0.3380 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7825.001 | 0.6054 | 0.4612 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7825.001 | 0.5645 | 0.3987 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7825.001 | 0.3468 | 0.0315 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9347.001 | 1.0205 | 1.0273 | 1.5003 |