Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7884.001 | 0.6801 | -0.0253 | 0.5364 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7884.001 | 0.7094 | 0.0545 | 0.5364 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7884.001 | 0.7259 | 0.1007 | 0.5364 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7884.001 | 0.5013 | -0.4481 | 0.5364 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7885.001 | 1.0465 | 1.1504 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7885.001 | 0.9814 | 0.9410 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7885.001 | 1.1294 | 1.4288 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7885.001 | 1.0237 | 1.0763 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7885.001 | 0.9306 | 0.7829 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7885.001 | 0.8017 | 0.4056 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7885.001 | 0.7895 | 0.3715 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7885.001 | 0.8254 | 0.4723 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7885.001 | 0.6858 | 0.0952 | 0.6265 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7886.001 | 0.9847 | 0.9617 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7886.001 | 1.0064 | 1.0160 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7886.001 | 1.0335 | 1.0841 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7886.001 | 1.0108 | 1.0270 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7886.001 | 0.8402 | 0.6088 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7886.001 | 0.7155 | 0.3159 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7886.001 | 0.7912 | 0.4924 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7886.001 | 0.7826 | 0.4720 | 0.7999 | |
MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7886.001 | 0.5396 | -0.0752 | 0.7999 | |
MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7892.001 | 0.9518 | 0.9628 | 2.6314 | |
MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7892.001 | 1.0150 | 1.0113 | 2.6314 | |
MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7892.001 | 1.0662 | 1.0493 | 2.6314 |