Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10077.001 | 0.8089 | 0.3997 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10077.001 | 0.7071 | 0.1160 | 0.5941 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7879.001 | 1.0145 | 1.0155 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7879.001 | 1.0003 | 1.0003 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7879.001 | 0.9962 | 0.9959 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7879.001 | 0.9218 | 0.9143 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7879.001 | 0.4127 | 0.2423 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7879.001 | 0.2584 | -0.0342 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7879.001 | 0.3052 | 0.0563 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7879.001 | 0.3306 | 0.1026 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7879.001 | 0.0999 | -0.4208 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10093.001 | 1.3090 | 2.1921 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10093.001 | 0.8158 | 0.4045 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10093.001 | 1.1106 | 1.3997 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10093.001 | 0.7496 | 0.2125 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10093.001 | 0.4747 | -0.4515 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10093.001 | 0.1890 | -0.8891 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10093.001 | 0.2372 | -0.8355 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10093.001 | 0.3352 | -0.7002 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10093.001 | 0.1172 | -0.9516 | 0.5759 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7884.001 | 0.9938 | 0.9768 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7884.001 | 0.9513 | 0.8224 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7884.001 | 1.0241 | 1.0907 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7884.001 | 0.9659 | 0.8746 | 0.5364 | |
| MDA-MB-175-VII | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7884.001 | 0.7760 | 0.2465 | 0.5364 |