Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9723.001 | 0.5728 | 0.1055 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9723.001 | 0.6730 | 0.3125 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9723.001 | 0.1862 | -0.6655 | 0.9400 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7904.001 | 0.8986 | 0.8522 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7904.001 | 0.9434 | 0.9179 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7904.001 | 0.2177 | -0.3314 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7904.001 | 0.1250 | -0.5513 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7904.001 | 0.1158 | -0.5751 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7904.001 | 0.2072 | -0.3547 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7904.001 | 0.3375 | -0.0837 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7904.001 | 0.6434 | 0.4568 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7904.001 | 0.3765 | -0.0087 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7905.001 | 0.9844 | 0.9582 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7905.001 | 1.1235 | 1.3391 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7905.001 | 0.9427 | 0.8473 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7905.001 | 0.3157 | -0.5760 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7905.001 | 0.0844 | -0.9281 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7905.001 | 0.1424 | -0.8547 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7905.001 | 0.2832 | -0.6336 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7905.001 | 0.5682 | -0.0652 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7905.001 | 0.1200 | -0.8845 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7906.001 | 0.8410 | 0.4747 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7906.001 | 1.2772 | 2.0758 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7906.001 | 0.7690 | 0.2600 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7906.001 | 0.6807 | 0.0166 | 0.5685 |