Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7902.001 | 0.4793 | 0.3678 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10266.001 | 1.0284 | 1.0701 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10266.001 | 1.1858 | 1.4660 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10266.001 | 0.9508 | 0.8798 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10266.001 | 0.9067 | 0.7733 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10266.001 | 0.5326 | -0.0777 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 10266.001 | 0.5233 | -0.0975 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 10266.001 | 0.5709 | 0.0044 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10266.001 | 0.6221 | 0.1162 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 10266.001 | 0.4636 | -0.2223 | 0.8138 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9708.001 | 0.9735 | 0.9476 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9708.001 | 1.1566 | 1.3084 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9708.001 | 0.8462 | 0.6964 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9708.001 | 0.6569 | 0.3215 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9708.001 | 0.4759 | -0.0382 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9708.001 | 0.5347 | 0.0788 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9708.001 | 0.5551 | 0.1194 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9708.001 | 0.4702 | -0.0497 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9708.001 | 0.4797 | -0.0307 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9723.001 | 1.0337 | 1.0717 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9723.001 | 1.0643 | 1.1370 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9723.001 | 1.0390 | 1.0832 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9723.001 | 0.6960 | 0.3602 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9723.001 | 0.4437 | -0.1575 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9723.001 | 0.4891 | -0.0655 | 0.9400 |