Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7906.001 | 0.0661 | -0.9832 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7906.001 | 0.0954 | -0.9679 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7906.001 | 0.2671 | -0.8039 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7906.001 | 0.4416 | -0.5251 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7906.001 | 0.3421 | -0.6970 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7907.001 | 0.9699 | 0.9545 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7907.001 | 1.2161 | 1.3167 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7907.001 | 0.8601 | 0.7858 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7907.001 | 0.4345 | 0.0691 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7907.001 | 0.0832 | -0.6914 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7907.001 | 0.1093 | -0.6211 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7907.001 | 0.2133 | -0.3736 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7907.001 | 0.5546 | 0.2843 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7907.001 | 0.2246 | -0.3488 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7909.001 | 0.9113 | 0.8866 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7909.001 | 1.1692 | 1.2065 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7909.001 | 0.3521 | 0.0377 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7909.001 | 0.1637 | -0.3587 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7909.001 | 0.1827 | -0.3130 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7909.001 | 0.2197 | -0.2287 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7909.001 | 0.3083 | -0.0455 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7909.001 | 0.7471 | 0.6651 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7909.001 | 0.4493 | 0.2096 | 1.5909 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9759.001 | 1.0138 | 1.0233 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9759.001 | 1.0816 | 1.1371 | 1.1834 |