Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7875.001 | 0.9263 | 0.8978 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7875.001 | 0.6554 | 0.4974 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7875.001 | 0.0019 | -0.9726 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9583.001 | 1.0158 | 1.0280 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9583.001 | 1.0335 | 1.0592 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9583.001 | 1.0162 | 1.0287 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9583.001 | 0.9104 | 0.8403 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9583.001 | 0.5577 | 0.1922 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9583.001 | 0.6424 | 0.3514 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9583.001 | 0.7036 | 0.4648 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9583.001 | 0.7670 | 0.5811 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9583.001 | 0.4943 | 0.0714 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10073.001 | 0.9920 | 0.9731 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10073.001 | 0.9724 | 0.9076 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10073.001 | 1.0165 | 1.0561 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10073.001 | 0.8387 | 0.4862 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10073.001 | 0.7872 | 0.3354 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10073.001 | 0.8710 | 0.5840 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10073.001 | 0.9092 | 0.7032 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10073.001 | 0.8543 | 0.5330 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10073.001 | 0.1188 | -0.9451 | 0.5923 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7876.001 | 0.9594 | 0.9172 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7876.001 | 1.0342 | 1.0698 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7876.001 | 1.0547 | 1.1116 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7876.001 | 0.9654 | 0.9295 | 0.9806 |