Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | GSK461364 | PLK1 | PLK | 33.3 | uM | 9566.001 | 0.0190 | -0.6935 | 2.1122 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10061.001 | 1.0623 | 1.0706 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10061.001 | 1.1422 | 1.1588 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10061.001 | 1.0393 | 1.0448 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10061.001 | 1.0741 | 1.0839 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10061.001 | 0.7391 | 0.6812 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 10061.001 | 0.6180 | 0.5168 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 10061.001 | 0.5903 | 0.4775 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10061.001 | 0.6276 | 0.5303 | 1.7406 | |
| MCF12A | NM | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 10061.001 | 0.0103 | -0.8558 | 1.7406 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7874.001 | 0.9152 | 0.8850 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7874.001 | 0.8976 | 0.8607 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7874.001 | 0.5579 | 0.3543 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7874.001 | 0.5373 | 0.3205 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7874.001 | 0.5494 | 0.3404 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7874.001 | 0.6875 | 0.5570 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7874.001 | 0.7794 | 0.6933 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7874.001 | 0.6837 | 0.5512 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7874.001 | 0.2917 | -0.1219 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7875.001 | 1.0351 | 1.0478 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7875.001 | 1.1073 | 1.1446 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7875.001 | 1.0361 | 1.0491 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7875.001 | 0.6311 | 0.4592 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7875.001 | 0.6764 | 0.5301 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7875.001 | 0.9117 | 0.8773 | 1.4600 |