Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9294.001 | 0.6659 | 0.1922 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9294.001 | 0.2514 | -0.6549 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10031.001 | 1.0190 | 1.0423 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10031.001 | 1.0407 | 1.0909 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10031.001 | 1.0212 | 1.0472 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10031.001 | 0.9767 | 0.9482 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10031.001 | 0.9411 | 0.8692 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10031.001 | 0.9980 | 0.9955 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10031.001 | 0.9076 | 0.7953 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10031.001 | 0.8184 | 0.6000 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10031.001 | 0.0155 | -0.9807 | 0.8981 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7825.001 | 0.9735 | 0.9667 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7825.001 | 1.0009 | 1.0011 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7825.001 | 0.7812 | 0.7139 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7825.001 | 0.6077 | 0.4647 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7825.001 | 0.5720 | 0.4102 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7825.001 | 0.6284 | 0.4958 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7825.001 | 0.7051 | 0.6074 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7825.001 | 0.4425 | 0.2011 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7825.001 | 0.1759 | -0.3253 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9347.001 | 1.0952 | 1.1250 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9347.001 | 0.9786 | 0.9713 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9347.001 | 1.0201 | 1.0267 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9347.001 | 1.0163 | 1.0216 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9347.001 | 0.6639 | 0.5221 | 1.5003 |