Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9278.001 | 1.0036 | 1.0161 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9278.001 | 1.0207 | 1.0947 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9278.001 | 1.0627 | 1.2945 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9278.001 | 1.0434 | 1.2014 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9278.001 | 0.7623 | 0.0836 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9278.001 | 0.9442 | 0.7570 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9278.001 | 1.0694 | 1.3269 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9278.001 | 0.9943 | 0.9745 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9278.001 | 0.6644 | -0.2055 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10019.001 | 1.0128 | 1.0652 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10019.001 | 1.0802 | 1.4291 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10019.001 | 1.0022 | 1.0111 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10019.001 | 1.0495 | 1.2591 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10019.001 | 0.9525 | 0.7691 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10019.001 | 0.9664 | 0.8349 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10019.001 | 1.1071 | 1.5847 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10019.001 | 0.9250 | 0.6433 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10019.001 | 0.1943 | -0.9678 | 0.3968 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9294.001 | 1.0078 | 1.0199 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9294.001 | 0.9612 | 0.9017 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9294.001 | 1.0080 | 1.0204 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9294.001 | 0.9994 | 0.9984 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9294.001 | 0.8663 | 0.6661 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9294.001 | 0.9169 | 0.7910 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9294.001 | 0.9215 | 0.8024 | 0.7859 |