Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9095.001 | 1.0321 | 1.0615 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9095.001 | 1.0950 | 1.1815 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9095.001 | 0.6379 | 0.3004 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9095.001 | 0.5628 | 0.1535 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9095.001 | 0.6103 | 0.2466 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9095.001 | 0.6887 | 0.3994 | 1.0444 | |
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9095.001 | 0.0116 | -0.9719 | 1.0444 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9118.001 | 0.9935 | 0.9881 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9118.001 | 1.0430 | 1.0783 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9118.001 | 0.9810 | 0.9653 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9118.001 | 1.0006 | 1.0010 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9118.001 | 0.8346 | 0.6956 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9118.001 | 1.0684 | 1.1247 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9118.001 | 1.0601 | 1.1096 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9118.001 | 0.7710 | 0.5771 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9118.001 | 0.7253 | 0.4914 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9120.001 | 1.0367 | 1.1200 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9120.001 | 1.0082 | 1.0267 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9120.001 | 0.9871 | 0.9584 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9120.001 | 0.9712 | 0.9077 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9120.001 | 0.6861 | 0.0870 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9120.001 | 0.9571 | 0.8631 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9120.001 | 0.9972 | 0.9909 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9120.001 | 0.9794 | 0.9336 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9120.001 | 0.0170 | -0.9973 | 0.6180 |