Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9186.001 | 0.9842 | 0.9392 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9186.001 | 0.8241 | 0.3752 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9186.001 | 0.7986 | 0.2940 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9186.001 | 0.8262 | 0.3818 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9186.001 | 0.8044 | 0.3121 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9186.001 | 0.0700 | -0.9884 | 0.5165 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10261.001 | 1.0622 | 1.0521 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10261.001 | 1.0395 | 1.0332 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10261.001 | 0.9864 | 0.9884 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10261.001 | 0.9262 | 0.9357 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10261.001 | 0.3841 | 0.3305 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 10261.001 | 0.3059 | 0.2075 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 10261.001 | 0.1699 | -0.0602 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10261.001 | 0.0825 | -0.3091 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 10261.001 | 0.0542 | -0.4222 | 2.3472 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9210.001 | 0.9582 | 0.9047 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9210.001 | 1.0095 | 1.0218 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9210.001 | 1.0214 | 1.0489 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9210.001 | 0.9646 | 0.9193 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9210.001 | 0.4576 | -0.1807 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9210.001 | 0.8479 | 0.6566 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9210.001 | 0.9280 | 0.8365 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9210.001 | 0.7885 | 0.5248 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9210.001 | 0.1108 | -0.8377 | 0.8761 | |
| HBL-100 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7808.001 | 0.9426 | 0.9539 | 2.5321 |