Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9158.001 | 0.9526 | 0.8659 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9158.001 | 1.0478 | 1.1383 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9158.001 | 0.9076 | 0.7409 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9158.001 | 0.0118 | -0.9965 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9163.001 | 1.0688 | 1.2716 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9163.001 | 1.0003 | 1.0011 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9163.001 | 1.0190 | 1.0733 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9163.001 | 1.0458 | 1.1787 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9163.001 | 0.5548 | -0.3521 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9163.001 | 0.7480 | 0.1477 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9163.001 | 0.9791 | 0.9206 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9163.001 | 0.8476 | 0.4575 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9163.001 | 0.0142 | -0.9994 | 0.5227 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7801.001 | 1.0497 | 1.1881 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7801.001 | 0.9482 | 0.8123 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7801.001 | 0.9768 | 0.9148 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7801.001 | 0.9960 | 0.9851 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7801.001 | 0.7326 | 0.1242 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7801.001 | 0.7760 | 0.2507 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7801.001 | 0.8494 | 0.4785 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7801.001 | 0.8147 | 0.3684 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7801.001 | 0.4664 | -0.5127 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9186.001 | 1.0113 | 1.0441 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9186.001 | 1.0106 | 1.0414 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9186.001 | 1.0390 | 1.1537 | 0.5165 |