Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9146.001 | 0.5077 | 0.1814 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9146.001 | 0.0049 | -0.9678 | 1.2878 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7798.001 | 1.0620 | 1.0900 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7798.001 | 1.0239 | 1.0349 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7798.001 | 0.8011 | 0.7004 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7798.001 | 0.6670 | 0.4870 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7798.001 | 0.6424 | 0.4467 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7798.001 | 0.8909 | 0.8379 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7798.001 | 1.0331 | 1.0482 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7798.001 | 0.9167 | 0.8768 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7798.001 | 0.5022 | 0.2083 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9157.001 | 1.0143 | 1.0310 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9157.001 | 1.0981 | 1.2138 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9157.001 | 1.0688 | 1.1498 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9157.001 | 0.8142 | 0.5999 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9157.001 | 0.6210 | 0.1922 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9157.001 | 0.7685 | 0.5027 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9157.001 | 0.9176 | 0.8217 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9157.001 | 0.8892 | 0.7605 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9157.001 | 0.0342 | -0.9488 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9158.001 | 1.0389 | 1.1124 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9158.001 | 1.0616 | 1.1787 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9158.001 | 1.1003 | 1.2933 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9158.001 | 0.9134 | 0.7569 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9158.001 | 0.5738 | -0.0968 | 0.6988 |