Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7512.098 | 0.8119 | 0.6061 | 0.9499 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7512.098 | 0.7467 | 0.4706 | 0.9499 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7515.092 | 0.9512 | 0.9186 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7515.092 | 0.8164 | 0.6896 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7515.092 | 0.9360 | 0.8930 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7515.092 | 0.9484 | 0.9138 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7515.092 | 0.9574 | 0.9289 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7515.092 | 0.9446 | 0.9074 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7515.092 | 0.9171 | 0.8611 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7515.092 | 0.9956 | 0.9927 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7515.092 | 1.0126 | 1.0210 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7515.098 | 0.9366 | 0.8889 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7515.098 | 0.9066 | 0.8361 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7515.098 | 0.9361 | 0.8881 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7515.098 | 0.9875 | 0.9781 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7515.098 | 0.9086 | 0.8395 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7515.098 | 0.9443 | 0.9026 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7515.098 | 0.9236 | 0.8660 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7515.098 | 0.0967 | -0.7393 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7515.098 | 0.1080 | -0.7130 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7516.092 | 1.0128 | 1.0231 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7516.092 | 0.9390 | 0.8891 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7516.092 | 0.9835 | 0.9700 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7516.092 | 0.9914 | 0.9845 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7516.092 | 1.0128 | 1.0231 | 1.1035 |