Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7877.001 | 0.8944 | 0.5489 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7877.001 | 0.8614 | 0.4213 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7877.001 | 0.8112 | 0.2387 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7877.001 | 0.7585 | 0.0620 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7877.001 | 0.5628 | -0.4638 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10077.001 | 1.0278 | 1.0946 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10077.001 | 0.9444 | 0.8165 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10077.001 | 1.0865 | 1.2996 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10077.001 | 0.9225 | 0.7461 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10077.001 | 1.0271 | 1.0921 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10077.001 | 0.9987 | 0.9957 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10077.001 | 0.9470 | 0.8249 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10077.001 | 0.7307 | 0.1795 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10077.001 | 0.4665 | -0.4458 | 0.5941 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7879.001 | 0.9969 | 0.9966 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7879.001 | 0.9842 | 0.9829 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7879.001 | 1.0380 | 1.0405 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7879.001 | 0.8890 | 0.8773 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7879.001 | 0.6101 | 0.5332 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7879.001 | 0.6762 | 0.6203 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7879.001 | 0.8406 | 0.8216 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7879.001 | 0.3876 | 0.2011 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7879.001 | 0.0136 | -0.8022 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10093.001 | 0.9575 | 0.8548 | 0.5759 | |
| MDA-MB-157 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 10093.001 | 0.7277 | 0.1517 | 0.5759 |