Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9583.001 | 0.9732 | 0.9524 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9583.001 | 0.8622 | 0.7538 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9583.001 | 0.3791 | -0.1532 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10073.001 | 1.0340 | 1.1162 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10073.001 | 0.9897 | 0.9655 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10073.001 | 0.9780 | 0.9261 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10073.001 | 0.9487 | 0.8298 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10073.001 | 0.9391 | 0.7986 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10073.001 | 0.9614 | 0.8714 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10073.001 | 0.9652 | 0.8840 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10073.001 | 0.9373 | 0.7930 | 0.5923 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10073.001 | 0.3938 | -0.5853 | 0.5923 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7876.001 | 0.9973 | 0.9945 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7876.001 | 0.9545 | 0.9072 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7876.001 | 0.9956 | 0.9911 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7876.001 | 0.9696 | 0.9381 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7876.001 | 0.9377 | 0.8731 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7876.001 | 0.8574 | 0.7095 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7876.001 | 0.8015 | 0.5960 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7876.001 | 0.6891 | 0.3680 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7876.001 | 0.4500 | -0.1142 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7877.001 | 1.0268 | 1.1248 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7877.001 | 0.9868 | 0.9400 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7877.001 | 1.0166 | 1.0767 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7877.001 | 0.9998 | 0.9989 | 0.4366 |