Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 10061.001 | 0.1397 | -0.3544 | 1.7406 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7874.001 | 0.9560 | 0.9408 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7874.001 | 0.9750 | 0.9665 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7874.001 | 0.9411 | 0.9204 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7874.001 | 0.8866 | 0.8455 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7874.001 | 0.9298 | 0.9050 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7874.001 | 0.8461 | 0.7887 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7874.001 | 0.8448 | 0.7869 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7874.001 | 0.7758 | 0.6879 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7874.001 | 0.0024 | -0.9647 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7875.001 | 1.1821 | 1.2429 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7875.001 | 1.0303 | 1.0414 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7875.001 | 1.0896 | 1.1211 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7875.001 | 0.9880 | 0.9836 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7875.001 | 1.0533 | 1.0725 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7875.001 | 1.0179 | 1.0244 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7875.001 | 1.0506 | 1.0688 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7875.001 | 0.8335 | 0.7655 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7875.001 | 0.0028 | -0.9646 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9583.001 | 1.0111 | 1.0197 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9583.001 | 0.9987 | 0.9976 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9583.001 | 0.9951 | 0.9913 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9583.001 | 0.9464 | 0.9047 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9583.001 | 0.9042 | 0.8294 | 1.1288 | |
| MCF7 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9583.001 | 0.9065 | 0.8334 | 1.1288 |