Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7475.084 | 1.2222 | 1.1496 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7475.084 | 1.1356 | 1.0936 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7475.084 | 0.0381 | -0.3825 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7475.084 | 0.0025 | -0.7694 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7475.084 | 0.0009 | -0.8415 | 2.7804 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7477.084 | 1.0267 | 1.0563 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7477.084 | 1.0606 | 1.1281 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7477.084 | 0.9673 | 0.9311 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7477.084 | 0.6677 | 0.3059 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7477.084 | 0.2167 | -0.6018 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7477.084 | 0.0013 | -0.9982 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7477.084 | 0.0013 | -0.9982 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7477.084 | 0.0013 | -0.9982 | 0.9476 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7477.084 | 0.0013 | -0.9982 | 0.9476 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7482.084 | 0.9972 | 0.9970 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7482.084 | 1.0106 | 1.0113 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7482.084 | 1.1480 | 1.1532 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7482.084 | 1.0919 | 1.0963 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7482.084 | 1.1653 | 1.1705 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7482.084 | 0.0171 | -0.7732 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7482.084 | 0.0083 | -0.8458 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7482.084 | 0.0097 | -0.8323 | 1.8697 | |
| MB 157 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7482.084 | 0.0014 | -0.9397 | 1.8697 | |
| MCF 10A | NM | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7483.084 | 0.9807 | 0.9881 | 3.2830 | |
| MCF 10A | NM | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7483.084 | 1.0033 | 1.0020 | 3.2830 |