Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7433.084 | 0.0071 | -0.9837 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7433.084 | 0.0100 | -0.9772 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7433.084 | 0.0016 | -0.9962 | 1.0291 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7435.084 | 0.9979 | 0.9950 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7435.084 | 0.9395 | 0.8607 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7435.084 | 0.9821 | 0.9587 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7435.084 | 0.9957 | 0.9901 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7435.084 | 0.9638 | 0.9165 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7435.084 | 0.7956 | 0.5352 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7435.084 | 0.0571 | -0.9271 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7435.084 | 0.0007 | -0.9996 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7435.084 | 0.0005 | -0.9997 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7436.085 | 1.0564 | 1.0889 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7436.085 | 0.9717 | 0.9550 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7436.085 | 1.0128 | 1.0203 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7436.085 | 0.9998 | 0.9997 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7436.085 | 0.9955 | 0.9929 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7436.085 | 0.8025 | 0.6800 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7436.085 | 0.0977 | -0.6832 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7436.085 | 0.0093 | -0.9507 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7436.085 | 0.0078 | -0.9575 | 1.2621 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7437.084 | 1.0097 | 1.0451 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7437.084 | 1.0193 | 1.0898 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7437.084 | 0.9720 | 0.8734 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7437.084 | 0.9524 | 0.7877 | 0.4343 |