Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7836.016 | 0.9724 | 0.9646 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.267 | uM | 7836.016 | 0.9295 | 0.9088 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 1.33 | uM | 7836.016 | 0.7542 | 0.6705 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 7836.016 | 0.5032 | 0.2903 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 33.3 | uM | 7836.016 | 0.1315 | -0.4521 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7837.016 | 0.7779 | 0.7405 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7837.016 | 0.8441 | 0.8209 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7837.016 | 0.7430 | 0.6968 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7837.016 | 0.8638 | 0.8444 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7837.016 | 0.9121 | 0.9007 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.267 | uM | 7837.016 | 0.7385 | 0.6911 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 1.33 | uM | 7837.016 | 0.4949 | 0.3549 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 7837.016 | 0.3735 | 0.1596 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 33.3 | uM | 7837.016 | 0.1317 | -0.3488 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7839.016 | 0.9659 | 0.9559 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7839.016 | 1.2822 | 1.3465 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7839.016 | 0.9803 | 0.9745 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7839.016 | 1.1162 | 1.1465 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7839.016 | 1.1553 | 1.1945 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.267 | uM | 7839.016 | 0.9591 | 0.9470 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 1.33 | uM | 7839.016 | 0.6550 | 0.5237 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 7839.016 | 0.4556 | 0.2066 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 33.3 | uM | 7839.016 | 0.0745 | -0.6232 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9386.132 | 0.9337 | 0.9049 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9386.132 | 0.9793 | 0.9705 | 1.4083 |