Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF 10A Omipalisib 5 5000.00
0.9091
0.0527
 0.3485 0.4540 0.8373 0.6865
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9132
0.5051
0.1697
 0.1929 0.2322 0.5727 0.3532
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.905
MCF 10A Etoposide 5 156.25
0.168
0.1629
 0.0407 0.0483 3.2995 0.4570
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9859
0.2686
0.2305
 0.1392 0.1716 2.7518 0.4294
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
MCF 10A Etoposide 5 312.50
0.1528
0.1488
 0.0290 0.0269 2.1234 0.4401
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.986
0.253
0.2536
 -0.0232 -0.0025 1.8816 0.5037
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9957
MCF 10A Etoposide 5 625.00
0.1298
0.1243
 0.0391 0.0304 1.4359 0.4305
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9916
0.2423
0.2536
 -0.0292 -0.0326 1.3961 0.5199
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9967
MCF 10A Etoposide 5 1250.00
0.1519
0.135
 0.0831 0.0756 1.3962 0.4633
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.993
0.2194
0.2279
 -0.0274 -0.0279 1.4189 0.5328
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9966
MCF 10A Etoposide 5 2500.00
0.1966
0.1514
 0.1761 0.1670 1.5552 0.5241
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9907
0.1745
0.1949
 -0.0951 -0.1018 1.6815 0.5979
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9945
MCF 10A Etoposide 5 5000.00
0.312
0.1693
 0.3228 0.3241 1.7089 0.6186
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9917
0.2405
0.1959
 0.1466 0.1532 1.7843 0.4628
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9939
MCF 10A Methotrexate 5 156.25
inf
inf
 0.8981 0.8981 0.0000 0.8919
flat fit: x = Einf
0.48
inf
inf
 0.9601 0.9601 0.0000 0.0371
flat fit: x = Einf
0.4776
MCF 10A Methotrexate 5 312.50
0.0904
0.0619
 0.4335 0.4252 4.9999 0.6777
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9859
inf
0.0621
 0.6855 0.6800 5.0000 0.1768
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9765
MCF 10A Methotrexate 5 625.00
0.0693
0.0609
 0.2455 0.2368 5.0000 0.5574
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9939
0.1018
0.0626
 0.4625 0.4561 5.0000 0.3165
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9967
MCF 10A Methotrexate 5 1250.00
0.0654
0.0585
 0.2120 0.2136 5.0000 0.5363
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9988
0.0728
0.0613
 0.2805 0.2882 5.0000 0.4179
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9988
MCF 10A Methotrexate 5 2500.00
0.071
0.0597
 0.2582 0.2667 4.3696 0.5631
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9981
0.0684
0.0647
 0.0899 0.1054 4.2563 0.5247
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9982
MCF 10A Methotrexate 5 5000.00
0.0997
0.0667
 0.4095 0.4267 4.7824 0.6640
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9977
0.0862
0.0696
 0.2918 0.3179 4.7041 0.3965
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9972
MCF 10A NVP-TAE684 6 156.25
0.1584
0.1291
 0.0798 0.1111 1.2296 0.5674
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9842
0.725
0.3893
 0.2264 0.2177 0.9192 0.2864
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9831
MCF 10A NVP-TAE684 6 312.50
0.333
0.314
 0.0561 0.0309 1.0843 0.6206
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9578
0.8558
0.8602
 0.0766 -0.0025 0.9727 0.2881
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9851
MCF 10A NVP-TAE684 6 625.00
0.3066
0.2824
 0.0427 0.0451 1.1451 0.6190
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9928
0.9744
1.241
 0.0323 -0.1146 0.8534 0.2822
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9953
MCF 10A NVP-TAE684 6 1250.00
0.7451
0.7007
 0.0595 0.0340 1.1449 0.7079
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9931
1.8816
3.8681
 0.0243 -0.4063 0.8252 0.2220
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
MCF 10A NVP-TAE684 6 2500.00
1.5012
1.5012
 0.1311 0.0000 0.8864 0.7652
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9941
2.4692
11.4294
 0.0377 -1.0000 0.7170 0.2052
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9947
MCF 10A NVP-TAE684 6 5000.00
3.3776
3.3776
 0.2879 0.0000 0.6861 0.8128
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9867
4.8284
28.7459
 0.2954 -1.0000 0.6158 0.1571
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9888
MCF 10A PLX-4720 6 156.25
12.9298
11.6383
 0.2544 0.2046 4.9999 0.9541
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9272
25.9434
12.9573
 0.5373 0.4844 4.9981 0.0161
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9397
MCF 10A PLX-4720 6 312.50
12.6794
11.7787
 0.2691 0.0884 2.6391 0.9165
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9311
19.9181
17.4172
 0.4980 0.1302 2.2475 0.0503
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9661
MCF 10A PLX-4720 6 625.00
11.1388
11.1388
 0.2294 0.0000 1.9396 0.9128
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
18.9631
36.248
 0.4695 -0.8508 1.5339 0.0500
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.997
MCF 10A PLX-4720 6 1250.00
13.4564
10.7233
 0.3545 0.3080 4.2153 0.9557
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9871
inf
12.0438
 0.5650 0.5067 3.9452 0.0279
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9919
MCF 10A PLX-4720 6 2500.00
inf
13.2079
 0.6102 0.5612 4.9995 1.0106
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9287
inf
13.6628
 0.7046 0.6607 5.0000 -0.0079
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9277
MCF 10A PLX-4720 6 5000.00
inf
inf
 0.9693 0.9693 0.0000 1.0326
flat fit: x = Einf
-0.9865
inf
inf
 0.9775 0.9775 0.0000 -0.0282
flat fit: x = Einf
-0.9471