Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Lapatinib | 8 | 312.50 | 9.5347 | 9.5347 | 0.4399 | 0.0000 | 5.0000 | 1.0092 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9395 | 7.0106 | 8.7333 | -0.3280 | -1.0000 | 5.0000 | 0.0412 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9873 |
| BT-20 | Lapatinib | 8 | 625.00 | 8.7908 | 3.8443 | 0.4963 | 0.4920 | 5.0000 | 0.9883 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9375 | 4.0077 | 3.8655 | 0.0905 | 0.0826 | 5.0000 | 0.0527 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9789 |
| BT-20 | Lapatinib | 8 | 1250.00 | 9.0203 | 4.2139 | 0.4956 | 0.4889 | 5.0000 | 0.9937 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9361 | 4.5784 | 4.2906 | 0.1510 | 0.1386 | 4.9999 | 0.0365 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9754 |
| BT-20 | Lapatinib | 8 | 2500.00 | inf | 3.5248 | 0.5359 | 0.5216 | 3.3390 | 0.9748 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9428 | 4.6863 | 3.6417 | 0.3077 | 0.2835 | 3.3185 | 0.0504 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9711 |
| BT-20 | Lapatinib | 8 | 5000.00 | 9.5347 | 5.5365 | 0.4891 | 0.2617 | 1.3630 | 0.9363 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9867 | 10.8123 | 7.16 | 0.5192 | 0.2134 | 1.3501 | 0.0573 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.991 |
| BT-20 | Erlotinib | 8 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| BT-20 | Erlotinib | 8 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0459 | flat fit: x = Einf | -21.7755 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| BT-20 | Erlotinib | 8 | 625.00 | inf | inf | 0.9104 | 0.9104 | 0.0000 | 1.0352 | flat fit: x = Einf | -0.6176 | inf | inf | 0.8433 | 0.8433 | 0.0000 | -0.0281 | flat fit: x = Einf | -0.0455 |
| BT-20 | Erlotinib | 8 | 1250.00 | inf | 11.3369 | 0.8226 | 0.8108 | 4.7547 | 1.0215 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7103 | inf | 11.1846 | 0.7235 | 0.7083 | 4.9990 | -0.0151 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8522 |
| BT-20 | Erlotinib | 8 | 2500.00 | inf | 5.59 | 0.6641 | 0.5937 | 1.0930 | 0.9376 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.931 | 25.1524 | 7.0602 | 0.5148 | 0.3633 | 1.0207 | 0.0928 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9516 |
| BT-20 | Erlotinib | 8 | 5000.00 | inf | 3.0095 | 0.5821 | 0.4929 | 0.7880 | 0.8773 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9913 | inf | 4.5163 | 0.6234 | 0.5036 | 0.7527 | 0.1043 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9926 |
| BT-20 | Linsitinib | 8 | 156.25 | 22.6687 | 22.6686 | 0.6469 | 0.0000 | 5.0000 | 1.0291 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8643 | 20.5215 | 25.5643 | 0.5432 | -1.0000 | 5.0000 | -0.0248 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9131 |
| BT-20 | Linsitinib | 8 | 312.50 | 24.9753 | 24.9751 | 0.7490 | 0.0000 | 5.0000 | 1.0346 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7579 | 18.8397 | 23.4692 | 0.3749 | -1.0000 | 5.0000 | -0.0231 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9418 |
| BT-20 | Linsitinib | 8 | 625.00 | 22.6679 | 22.6677 | 0.6469 | 0.0000 | 5.0000 | 1.0339 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8481 | 18.8557 | 23.4891 | 0.3767 | -1.0000 | 5.0000 | -0.0232 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9416 |
| BT-20 | Linsitinib | 8 | 1250.00 | 23.7036 | 23.7008 | 0.6997 | 0.0003 | 5.0000 | 1.0205 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8798 | 20.2359 | 25.196 | 0.5209 | -0.9963 | 5.0000 | -0.0206 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9335 |
| BT-20 | Linsitinib | 8 | 2500.00 | 28.59 | 28.59 | 0.6453 | 0.0000 | 1.7236 | 0.9737 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8968 | 19.7438 | 38.3126 | 0.4871 | -1.0000 | 1.6572 | 0.0436 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9237 |
| BT-20 | Linsitinib | 8 | 5000.00 | 63.7717 | 63.179 | 0.7103 | 0.0036 | 0.7800 | 0.9573 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9502 | 68.9564 | 172.3672 | 0.7534 | -0.4985 | 0.7550 | 0.0356 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9583 |
| BT-20 | 17-AAG | 8 | 156.25 | inf | 0.004 | 0.5003 | 0.5746 | 4.9866 | 0.8088 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.961 | 0.0064 | 0.0041 | 0.3118 | 0.4291 | 4.4957 | 0.2611 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.962 |
| BT-20 | 17-AAG | 8 | 312.50 | inf | 0.0059 | 0.5057 | 0.5217 | 2.6740 | 0.7954 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9758 | 0.0054 | 0.006 | -0.1993 | -0.1651 | 2.7285 | 0.5246 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.992 |
| BT-20 | 17-AAG | 8 | 625.00 | 0.0076 | 0.0051 | 0.4493 | 0.4309 | 5.0000 | 0.7441 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9837 | 0.0052 | 0.0053 | 0.0035 | -0.0328 | 5.0000 | 0.4782 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9914 |
| BT-20 | 17-AAG | 8 | 1250.00 | 0.0112 | 0.0085 | 0.3406 | 0.3696 | 5.0000 | 0.7547 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9844 | 0.0084 | 0.0087 | -0.1379 | -0.0809 | 5.0000 | 0.4359 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9927 |
| BT-20 | 17-AAG | 8 | 2500.00 | 0.0163 | 0.0121 | 0.2918 | 0.3180 | 3.3605 | 0.7610 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9892 | 0.0124 | 0.0131 | -0.1322 | -0.0895 | 2.9714 | 0.3817 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9933 |
| BT-20 | 17-AAG | 8 | 5000.00 | 0.0309 | 0.0205 | 0.2876 | 0.2989 | 2.2161 | 0.7703 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9983 | 0.0338 | 0.0241 | 0.2387 | 0.2537 | 2.0877 | 0.2283 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9981 |
| BT-20 | Lapatinib | 9 | 156.25 | 9.1496 | 9.1495 | 0.3896 | 0.0000 | 5.0000 | 0.9912 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9571 | 6.5757 | 8.1916 | -0.4640 | -1.0000 | 5.0000 | 0.0640 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9909 |
| BT-20 | Lapatinib | 9 | 312.50 | 7.4145 | 5.3904 | 0.4244 | 0.3981 | 4.9893 | 0.9968 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9489 | 4.8826 | 5.3604 | -0.2411 | -0.2965 | 4.9871 | 0.0536 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.988 |