Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
SK-BR-3 Omipalisib 4 625.00
0.0852
0.0105
 0.3124 0.3119 0.4672 0.5141
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9792
0.0015
0.0075
 -0.5564 -0.5590 0.4732 1.1437
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9808
SK-BR-3 Omipalisib 4 1250.00
0.0238
0.0041
 0.2843 0.2970 0.5136 0.4470
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9713
0.0014
0.0042
 -0.4220 -0.3951 0.5169 1.0958
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9709
SK-BR-3 Omipalisib 4 2500.00
0.0157
0.0048
 0.2424 0.2893 0.7291 0.4205
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9658
0.0018
0.0043
 -0.5928 -0.4950 0.7690 1.2381
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9655
SK-BR-3 Omipalisib 4 5000.00
0.0238
0.0054
 0.3025 0.3074 0.6433 0.4493
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9946
0.0011
0.0038
 -0.6305 -0.6187 0.6750 1.3387
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9959
SK-BR-3 Etoposide 4 156.25
44.438
44.4379
 0.5278 0.0000 0.5271 0.8919
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6869
0.4691
0.5028
 -0.8379 -0.1969 4.7886 0.3952
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.602
SK-BR-3 Etoposide 4 312.50
inf
0.7853
 0.4794 0.5041 1.3097 0.8394
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9614
0.3229
0.5094
 -0.6441 -0.5454 1.6175 0.6106
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9843
SK-BR-3 Etoposide 4 625.00
2.4872
0.452
 0.4288 0.4612 1.4991 0.7633
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8949
0.2759
0.3788
 -0.4048 -0.3254 1.5804 0.6311
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8894
SK-BR-3 Etoposide 4 1250.00
1.3592
0.4605
 0.3284 0.3120 0.9036 0.6953
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9756
0.2522
0.469
 -0.3352 -0.3715 0.8959 0.6066
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9792
SK-BR-3 Etoposide 4 2500.00
0.6596
0.3025
 0.3343 0.3568 1.6034 0.6836
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9725
0.2129
0.294
 -0.3909 -0.3452 1.6269 0.6710
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9733
SK-BR-3 Etoposide 4 5000.00
0.5127
0.2509
 0.3589 0.3844 2.0491 0.6932
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.989
0.1768
0.2332
 -0.4793 -0.4243 2.2178 0.7297
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9923
SK-BR-3 Methotrexate 4 156.25
inf
inf
 0.8956 0.8956 0.0000 1.0226
flat fit: x = Einf
0.3911
inf
inf
 0.8899 0.8899 0.0000 -0.0382
flat fit: x = Einf
0.1473
SK-BR-3 Methotrexate 4 312.50
inf
inf
 1.0156 1.0156 0.0000 1.0075
flat fit: x = Einf
-0.0358
inf
inf
 1.0500 1.0500 0.0000 0.0501
flat fit: x = Einf
0.0605
SK-BR-3 Methotrexate 4 625.00
inf
inf
 0.8619 0.8619 0.0000 0.9888
flat fit: x = Einf
0.2661
inf
inf
 0.6518 0.6518 0.0000 0.0576
flat fit: x = Einf
0.2546
SK-BR-3 Methotrexate 4 1250.00
inf
0.1053
 0.8413 0.8405 2.8673 0.9286
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9166
inf
0.105
 0.6913 0.6891 2.8004 0.1497
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9639
SK-BR-3 Methotrexate 4 2500.00
inf
0.0692
 0.5510 0.5719 4.0705 0.7580
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9916
0.0709
0.0684
 0.0215 0.0658 3.9828 0.5353
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9954
SK-BR-3 Methotrexate 4 5000.00
0.1528
0.0744
 0.4778 0.4730 4.0589 0.7051
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9977
0.0632
0.0712
 -0.3001 -0.3096 4.0522 0.7405
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9983
SK-BR-3 NVP-TAE684 5 156.25
inf
1.5276
 0.6526 0.6052 1.0995 0.9311
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8639
17.4626
1.6878
 0.5351 0.4530 1.0118 0.1006
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8773
SK-BR-3 NVP-TAE684 5 312.50
inf
3.2987
 0.6129 0.5808 2.2343 0.9710
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8878
2.9445
3.0164
 0.0357 -0.0280 2.2601 0.1248
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9344
SK-BR-3 NVP-TAE684 5 625.00
3.8624
2.0408
 0.4824 0.4794 5.0000 0.9284
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.971
2.1286
2.0786
 0.0627 0.0560 5.0000 0.1491
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9896
SK-BR-3 NVP-TAE684 5 1250.00
2.904
1.9623
 0.4389 0.4296 5.0000 0.9255
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9722
1.9993
1.9619
 0.0583 0.0451 5.0000 0.1459
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9883
SK-BR-3 NVP-TAE684 5 2500.00
2.8672
1.8417
 0.4518 0.4453 5.0000 0.9100
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9838
1.9062
1.8545
 0.0748 0.0642 5.0000 0.1624
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9924
SK-BR-3 NVP-TAE684 5 5000.00
5.1697
2.131
 0.4823 0.4806 3.6643 0.9165
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9921
3.7519
2.2452
 0.4255 0.4231 3.6452 0.0916
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9944
SK-BR-3 PLX-4720 5 156.25
inf
inf
 1.0016 1.0016 0.0000 1.0376
flat fit: x = Einf
-3.2326
inf
inf
 1.0117 1.0117 0.0000 -0.0389
flat fit: x = Einf
-4.2879
SK-BR-3 PLX-4720 5 312.50
inf
inf
 0.9060 0.9060 0.0000 0.9743
flat fit: x = Einf
0.0495
inf
inf
 0.7252 0.7252 0.0000 0.1141
flat fit: x = Einf
0.2187
SK-BR-3 PLX-4720 5 625.00
inf
inf
 1.0213 1.0213 0.0000 1.0489
flat fit: x = Einf
-26.9944
inf
inf
 1.0420 1.0420 0.0000 -0.0497
flat fit: x = Einf
-381.2868