Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
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MDA-MB-231 | Omipalisib | 11 | 156.25 | 0.1358 | 0.0594 | 0.2740 | 0.2830 | 1.0087 | 0.5821 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9607 | 0.0375 | 0.0462 | -0.1059 | -0.0926 | 0.8136 | 0.6658 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.948 |
MDA-MB-231 | Omipalisib | 11 | 312.50 | 0.1027 | 0.0479 | 0.2070 | 0.2144 | 0.7347 | 0.5282 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9914 | 0.0491 | 0.0704 | -0.1012 | -0.1199 | 0.5964 | 0.6228 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9889 |
MDA-MB-231 | Omipalisib | 11 | 625.00 | 0.0659 | 0.0296 | 0.2185 | 0.2365 | 0.8015 | 0.5000 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9889 | 0.0302 | 0.0357 | -0.0810 | -0.0599 | 0.6764 | 0.6668 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.99 |
MDA-MB-231 | Omipalisib | 11 | 1250.00 | 0.0759 | 0.0313 | 0.2166 | 0.2306 | 0.6989 | 0.5049 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9864 | 0.0335 | 0.0414 | -0.0702 | -0.0663 | 0.5890 | 0.6491 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.978 |
MDA-MB-231 | Omipalisib | 11 | 2500.00 | 0.1448 | 0.0411 | 0.2689 | 0.2424 | 0.5267 | 0.5418 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9975 | 0.0325 | 0.0481 | -0.0623 | -0.1074 | 0.4971 | 0.6514 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9939 |
MDA-MB-231 | Omipalisib | 11 | 5000.00 | 1.5766 | 0.5936 | 0.3697 | 0.1486 | 0.3610 | 0.6706 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9957 | 0.1077 | 0.7877 | -0.2338 | -0.6482 | 0.4177 | 0.5832 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9938 |
BT-20 | NVP-TAE684 | 3 | 156.25 | 4.8641 | 2.9659 | 0.3686 | 0.3105 | 1.9617 | 0.9242 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9744 | 2.3148 | 3.1061 | -0.2096 | -0.3536 | 1.8191 | 0.1687 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9919 |
BT-20 | NVP-TAE684 | 3 | 312.50 | 3.7935 | 2.1702 | 0.3887 | 0.3767 | 2.5072 | 0.9225 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9697 | 1.9558 | 2.2149 | -0.1500 | -0.1775 | 2.4417 | 0.1730 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9903 |
BT-20 | NVP-TAE684 | 3 | 625.00 | 2.9826 | 2.4087 | 0.2572 | 0.2501 | 3.2454 | 0.9075 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9802 | 2.2539 | 2.5629 | -0.2412 | -0.2565 | 3.2228 | 0.1669 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9919 |
BT-20 | NVP-TAE684 | 3 | 1250.00 | 2.4485 | 1.7399 | 0.3578 | 0.3576 | 3.6764 | 0.9045 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9769 | 1.8738 | 1.8372 | 0.0359 | 0.0345 | 3.6151 | 0.1553 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.989 |
BT-20 | NVP-TAE684 | 3 | 2500.00 | 2.5949 | 1.8812 | 0.3282 | 0.3263 | 3.2875 | 0.8988 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9809 | 1.954 | 1.997 | -0.0315 | -0.0365 | 3.2405 | 0.1638 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.991 |
BT-20 | NVP-TAE684 | 3 | 5000.00 | 3.4169 | 2.2807 | 0.3655 | 0.3594 | 3.1387 | 0.9070 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9858 | 2.2559 | 2.3698 | -0.0710 | -0.0830 | 3.1156 | 0.1609 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9937 |
BT-20 | PLX-4720 | 3 | 156.25 | 23.4882 | 23.4881 | 0.6867 | 0.0000 | 5.0000 | 1.0144 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8645 | 19.1631 | 23.872 | 0.4111 | -1.0000 | 5.0000 | 0.0034 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9432 |
BT-20 | PLX-4720 | 3 | 312.50 | 24.832 | 24.8319 | 0.7435 | 0.0000 | 5.0000 | 1.0365 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7551 | 20.3724 | 25.3785 | 0.5302 | -1.0000 | 5.0000 | -0.0293 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9073 |
BT-20 | PLX-4720 | 3 | 625.00 | 27.1685 | 27.1647 | 0.8198 | 0.0004 | 5.0000 | 1.0403 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5695 | 23.3287 | 29.055 | 0.7300 | -0.9984 | 5.0000 | -0.0373 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7686 |
BT-20 | PLX-4720 | 3 | 1250.00 | 27.4271 | 27.4199 | 0.8264 | 0.0007 | 5.0000 | 1.0383 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5656 | 24.1694 | 30.0978 | 0.7686 | -0.9973 | 5.0000 | -0.0371 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7165 |
BT-20 | PLX-4720 | 3 | 2500.00 | inf | 17.7176 | 0.7649 | 0.6333 | 4.7685 | 1.0173 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8524 | 26.7937 | 19.9517 | 0.6797 | 0.3633 | 4.3971 | -0.0162 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9014 |
BT-20 | PLX-4720 | 3 | 5000.00 | inf | 10.2702 | 0.7747 | 0.7666 | 4.9996 | 1.0098 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8661 | inf | 10.3841 | 0.6474 | 0.6340 | 5.0000 | -0.0059 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9152 |
BT-20 | Palbociclib | 3 | 156.25 | 26.2184 | 26.2184 | 0.5812 | 0.0000 | 1.4198 | 0.9376 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8603 | 11.6786 | 23.4356 | 0.1132 | -1.0000 | 1.5773 | 0.1274 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8903 |
BT-20 | Palbociclib | 3 | 312.50 | inf | 0.1305 | 0.5804 | 0.6126 | 1.8634 | 0.7943 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9551 | 0.3282 | 0.183 | 0.2493 | 0.2802 | 1.4064 | 0.3669 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9706 |
BT-20 | Palbociclib | 3 | 625.00 | inf | 0.0375 | 0.5123 | 0.6394 | 1.6869 | 0.7255 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.6093 | 0.0394 | 0.0262 | 0.1837 | 0.4346 | 5.0000 | 0.4701 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5401 |
BT-20 | Palbociclib | 3 | 1250.00 | 1.0299 | 0.2199 | 0.3688 | 0.3792 | 0.9199 | 0.6834 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9547 | 0.2257 | 0.2381 | -0.0304 | -0.0221 | 0.8106 | 0.5158 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9614 |
BT-20 | Palbociclib | 3 | 2500.00 | 0.8767 | 0.2413 | 0.3802 | 0.3855 | 1.1424 | 0.6849 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9943 | 0.3481 | 0.2763 | 0.1045 | 0.1147 | 1.1275 | 0.4411 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9925 |
BT-20 | Palbociclib | 3 | 5000.00 | inf | 0.1503 | 0.5045 | 0.5000 | 0.9422 | 0.7166 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9475 | 0.2708 | 0.1658 | 0.1953 | 0.1879 | 0.9611 | 0.4532 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.95 |
BT-20 | Nilotinib | 3 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.9620 | flat fit: x = Einf | 0.0745 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0953 | flat fit: x = Einf | 0.0963 |