Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | PLX-4720 | 4 | 312.50 | inf | inf | 0.8842 | 0.8842 | 0.0000 | 1.0420 | flat fit: x = Einf | 0.1938 | 21.5364 | 26.8285 | 0.6227 | -1.0000 | 5.0000 | -0.0330 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8666 |
| SK-BR-3 | PLX-4720 | 4 | 625.00 | inf | inf | 0.9385 | 0.9385 | 0.0000 | 1.0285 | flat fit: x = Einf | -0.0581 | inf | inf | 0.8412 | 0.8412 | 0.0000 | -0.0107 | flat fit: x = Einf | 0.3221 |
| SK-BR-3 | PLX-4720 | 4 | 1250.00 | inf | inf | 0.8987 | 0.8987 | 0.0000 | 1.0026 | flat fit: x = Einf | 0.3544 | inf | inf | 0.8017 | 0.8017 | 0.0000 | 0.0098 | flat fit: x = Einf | 0.4042 |
| SK-BR-3 | PLX-4720 | 4 | 2500.00 | 30.4928 | 28.5664 | 0.8747 | 0.1388 | 4.9842 | 1.0241 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5361 | 23.3203 | 29.0101 | 0.7307 | -0.9895 | 5.0000 | -0.0231 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.811 |
| SK-BR-3 | PLX-4720 | 4 | 5000.00 | inf | 20.7343 | 0.8925 | 0.7691 | 4.0267 | 1.0221 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5582 | inf | 16.1826 | 0.7228 | 0.6258 | 4.9548 | -0.0260 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8287 |
| SK-BR-3 | Palbociclib | 4 | 156.25 | inf | inf | 0.8055 | 0.8055 | 0.0000 | 0.8441 | flat fit: x = Einf | 0.0 | inf | inf | 0.0729 | 0.0729 | 0.0000 | 0.5736 | flat fit: x = Einf | 0.0 |
| SK-BR-3 | Palbociclib | 4 | 312.50 | inf | 15.271 | 0.6458 | 0.3907 | 0.2613 | 0.8339 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.6797 | 0.1742 | 13.9022 | -0.1352 | -1.0000 | 0.2508 | 0.5642 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.6938 |
| SK-BR-3 | Palbociclib | 4 | 625.00 | 88.3847 | 2.7508 | 0.5710 | 0.3830 | 0.4187 | 0.8094 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8867 | 0.4847 | 1.8088 | -0.0336 | -0.3905 | 0.4383 | 0.4665 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8809 |
| SK-BR-3 | Palbociclib | 4 | 1250.00 | 65.9352 | 5.9794 | 0.5613 | 0.2385 | 0.2701 | 0.7559 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9678 | 0.4581 | 6.074 | 0.1328 | -0.5088 | 0.2716 | 0.4813 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9685 |
| SK-BR-3 | Palbociclib | 4 | 2500.00 | inf | 0.1161 | 0.5668 | 0.5271 | 0.4329 | 0.7338 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.966 | 0.0931 | 0.1118 | 0.0539 | -0.0400 | 0.4209 | 0.5874 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9629 |
| SK-BR-3 | Palbociclib | 4 | 5000.00 | inf | 0.2557 | 0.5744 | 0.5392 | 0.4272 | 0.7706 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.938 | 0.0908 | 0.1534 | -0.0914 | -0.1352 | 0.4567 | 0.6159 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9394 |
| SK-BR-3 | Nilotinib | 4 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0086 | flat fit: x = Einf | -0.031 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0510 | flat fit: x = Einf | 0.0675 |
| SK-BR-3 | Nilotinib | 4 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0466 | flat fit: x = Einf | -6.9372 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| SK-BR-3 | Nilotinib | 4 | 625.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0490 | flat fit: x = Einf | -86.9229 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| SK-BR-3 | Nilotinib | 4 | 1250.00 | inf | 4.4047 | 0.7108 | 0.7932 | 5.0000 | 0.9728 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7381 | inf | 4.449 | 0.4243 | 0.5931 | 5.0000 | 0.0712 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7608 |
| SK-BR-3 | Nilotinib | 4 | 2500.00 | inf | 5.0716 | 0.4695 | 0.5165 | 5.0000 | 0.9438 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9547 | 5.0195 | 5.0654 | -0.1195 | -0.0233 | 4.9998 | 0.1390 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9665 |
| SK-BR-3 | Nilotinib | 4 | 5000.00 | 8.4953 | 5.3796 | 0.4286 | 0.4265 | 4.1972 | 0.9357 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9871 | 4.6098 | 5.2223 | -0.3418 | -0.3456 | 4.2128 | 0.1728 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.995 |
| SK-BR-3 | Taxol | 4 | 156.25 | inf | 0.0028 | 0.7370 | 0.7912 | 5.0000 | 0.8747 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9006 | 0.0023 | 0.0021 | 0.0637 | 0.2222 | 5.0000 | 0.5333 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7269 |
| SK-BR-3 | Taxol | 4 | 312.50 | inf | 0.0014 | 0.6002 | 0.6182 | 5.0000 | 0.7239 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9239 | 0.0013 | 0.0014 | -0.2799 | -0.2159 | 5.0000 | 0.8976 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9473 |
| SK-BR-3 | Taxol | 4 | 625.00 | 0.0129 | 0.0026 | 0.4814 | 0.4936 | 2.6824 | 0.6506 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.982 | 0.0021 | 0.0024 | -0.2236 | -0.1974 | 2.5914 | 0.8331 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9872 |
| SK-BR-3 | Taxol | 4 | 1250.00 | 0.005 | 0.003 | 0.4103 | 0.4052 | 3.1391 | 0.6022 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9928 | 0.0027 | 0.003 | -0.1691 | -0.1791 | 3.1539 | 0.7911 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9953 |
| SK-BR-3 | Taxol | 4 | 2500.00 | 0.0044 | 0.0035 | 0.3190 | 0.3512 | 4.9999 | 0.5873 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.992 | 0.003 | 0.0034 | -0.4463 | -0.3823 | 5.0000 | 0.8850 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9949 |
| SK-BR-3 | Taxol | 4 | 5000.00 | 0.0052 | 0.0039 | 0.3751 | 0.3832 | 5.0000 | 0.6138 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.995 | 0.0033 | 0.0038 | -0.4986 | -0.4860 | 5.0000 | 0.9423 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9982 |
| SK-BR-3 | Omipalisib | 4 | 156.25 | 7.5041 | 1.7066 | 0.4708 | 0.1971 | 0.3383 | 0.7382 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8205 | 0.0109 | 0.0346 | -0.7437 | -0.6089 | 0.6904 | 1.0083 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8375 |
| SK-BR-3 | Omipalisib | 4 | 312.50 | 2.1766 | 2.1766 | 0.4118 | 0.0000 | 0.1607 | 0.6107 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9056 | -inf | 0.0093 | -0.6565 | -1.0000 | 0.1891 | 1.2212 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8894 |