Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
BT-20 Methotrexate 3 625.00
12.7108
12.2258
 0.7553 0.0884 5.0000 0.9853
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.511
inf
inf
 0.5612 0.5612 0.0000 0.0625
flat fit: x = Einf
0.4448
BT-20 Methotrexate 3 1250.00
inf
inf
 0.9085 0.9085 0.0000 0.9858
flat fit: x = Einf
0.4105
inf
inf
 0.8658 0.8658 0.0000 0.0388
flat fit: x = Einf
0.3205
BT-20 Methotrexate 3 2500.00
inf
0.0866
 0.6073 0.6506 5.0000 0.8124
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9688
inf
0.0887
 0.4708 0.5386 5.0000 0.2497
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9667
BT-20 Methotrexate 3 5000.00
inf
0.1004
 0.4861 0.5091 2.2595 0.7424
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9828
0.1369
0.1068
 0.1643 0.1993 2.0464 0.4147
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9846
BT-20 NVP-TAE684 4 156.25
3.3458
1.2865
 0.4236 0.4415 2.2452 0.8973
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9663
0.9059
1.1161
 -0.3827 -0.3248 2.3985 0.2908
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9858
BT-20 NVP-TAE684 4 312.50
2.2326
1.6422
 0.3218 0.3222 3.3666 0.8929
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9794
1.454
1.6739
 -0.2981 -0.2996 3.3346 0.2323
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9937
BT-20 NVP-TAE684 4 625.00
1.838
1.3623
 0.2442 0.2543 2.3716 0.8461
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9776
1.3203
1.5865
 -0.2256 -0.2372 2.1144 0.2487
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9858
BT-20 NVP-TAE684 4 1250.00
2.5924
2.0725
 0.2424 0.2341 2.8206 0.8828
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9856
2.0395
2.2705
 -0.1533 -0.1722 2.7574 0.1798
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
BT-20 NVP-TAE684 4 2500.00
2.7229
2.1662
 0.2591 0.2528 3.0802 0.8829
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9916
2.2088
2.3626
 -0.0991 -0.1128 3.0237 0.1696
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9948
BT-20 NVP-TAE684 4 5000.00
3.5506
2.4061
 0.3072 0.2558 1.8418 0.8743
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9942
2.2664
2.6479
 -0.0752 -0.1675 1.8570 0.1857
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9957
BT-20 PLX-4720 4 156.25
inf
inf
 0.8655 0.8655 0.0000 1.0355
flat fit: x = Einf
0.4446
21.958
27.3526
 0.6515 -0.9997 5.0000 -0.0341
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8479
BT-20 PLX-4720 4 312.50
inf
inf
 0.8555 0.8555 0.0000 1.0423
flat fit: x = Einf
0.389
23.4797
29.2472
 0.7375 -0.9994 5.0000 -0.0376
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7578
BT-20 PLX-4720 4 625.00
inf
15.9659
 0.7003 0.5038 1.8581 0.9917
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8963
23.816
19.7846
 0.5648 0.1389 1.7544 0.0217
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9345
BT-20 PLX-4720 4 1250.00
23.8927
23.8926
 0.7060 0.0000 5.0000 1.0263
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.845
21.4082
26.6681
 0.6140 -0.9998 5.0000 -0.0241
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8958
BT-20 PLX-4720 4 2500.00
inf
12.0049
 0.6032 0.5615 4.4079 0.9969
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9433
18.7391
12.2913
 0.4825 0.4216 4.3924 0.0104
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9627
BT-20 PLX-4720 4 5000.00
62.9954
23.0622
 0.6994 0.3457 1.1697 0.9687
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9721
26.5658
27.6747
 0.5824 -0.0242 1.1573 0.0448
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9835
BT-20 Palbociclib 4 156.25
inf
inf
 0.9482 0.9482 0.0000 0.8173
flat fit: x = Einf
0.2919
inf
inf
 0.7722 0.7722 0.0000 0.4184
flat fit: x = Einf
0.4764
BT-20 Palbociclib 4 312.50
inf
0.0579
 0.4611 0.5143 1.0098 0.6865
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9248
0.0803
0.0626
 0.0121 0.1049 0.9467 0.5703
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9296
BT-20 Palbociclib 4 625.00
0.81
0.0387
 0.4212 0.3901 0.4979 0.5944
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9032
0.0519
0.0431
 0.0875 0.0454 0.5152 0.6287
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9057
BT-20 Palbociclib 4 1250.00
0.4745
0.1309
 0.3239 0.3370 0.8701 0.6204
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9418
0.1592
0.1531
 -0.0147 0.0167 0.8760 0.5445
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9466
BT-20 Palbociclib 4 2500.00
0.3058
0.0771
 0.3408 0.3072 0.6917 0.5643
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9608
0.0998
0.0951
 0.0565 0.0181 0.7556 0.6010
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9649
BT-20 Palbociclib 4 5000.00
0.6018
0.0792
 0.3844 0.3405 0.5635 0.5951
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9286
0.0999
0.0953
 0.0701 0.0142 0.6059 0.5919
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9333
BT-20 Nilotinib 4 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0385
flat fit: x = Einf
-2.1987
inf
inf
 1.0500 1.0500 0.0000 -0.0346
flat fit: x = Einf
-1.0221
BT-20 Nilotinib 4 312.50
inf
inf
 1.0500 1.0500 0.0000 1.0500
flat fit: x = Einf
-inf
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
BT-20 Nilotinib 4 625.00
inf
inf
 1.0500 1.0500 0.0000 1.0430
flat fit: x = Einf
-7.0398
inf
inf
 1.0500 1.0500 0.0000 -0.0428
flat fit: x = Einf
-6.6624