Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
SK-BR-3 Omipalisib 5 2500.00
0.0756
0.006
 0.3998 0.4081 0.6692 0.5334
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9861
0.0064
0.0069
 -0.0398 -0.0244 0.6646 0.7960
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.986
SK-BR-3 Omipalisib 5 5000.00
0.3986
0.006
 0.4563 0.4779 0.7430 0.5807
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9901
0.0835
0.0079
 0.3819 0.4099 0.7266 0.4597
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9876
SK-BR-3 Etoposide 5 156.25
inf
inf
 0.8792 0.8792 0.0000 0.9787
flat fit: x = Einf
0.443
inf
inf
 0.8517 0.8517 0.0000 0.0288
flat fit: x = Einf
0.4507
SK-BR-3 Etoposide 5 312.50
inf
0.7264
 0.7070 0.7310 5.0000 0.8931
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7514
0.9345
0.7287
 0.3072 0.3559 5.0000 0.2873
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7271
SK-BR-3 Etoposide 5 625.00
inf
0.3004
 0.5453 0.5848 4.9999 0.7989
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9557
0.4141
0.3201
 0.1828 0.2447 2.6109 0.3631
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9592
SK-BR-3 Etoposide 5 1250.00
inf
0.2907
 0.4493 0.5061 2.2249 0.7696
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.963
0.3976
0.3185
 0.0779 0.1674 1.8392 0.3845
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9678
SK-BR-3 Etoposide 5 2500.00
0.8367
0.2491
 0.4458 0.4969 4.1938 0.7474
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9816
0.2767
0.2518
 0.0635 0.1569 3.9888 0.4226
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9823
SK-BR-3 Etoposide 5 5000.00
inf
0.1967
 0.4999 0.5167 2.8746 0.7396
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9925
0.5778
0.2086
 0.4493 0.4713 2.8061 0.2799
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.992
SK-BR-3 Methotrexate 5 156.25
inf
inf
 0.9985 0.9985 0.0000 1.0139
flat fit: x = Einf
-0.1029
inf
inf
 1.0031 1.0031 0.0000 -0.0031
flat fit: x = Einf
-0.0125
SK-BR-3 Methotrexate 5 312.50
inf
inf
 0.9138 0.9138 0.0000 1.0248
flat fit: x = Einf
-0.4512
inf
inf
 0.6562 0.6562 0.0000 0.0021
flat fit: x = Einf
0.2864
SK-BR-3 Methotrexate 5 625.00
inf
inf
 0.9548 0.9548 0.0000 1.0262
flat fit: x = Einf
-0.7227
inf
inf
 0.9242 0.9242 0.0000 -0.0198
flat fit: x = Einf
-0.2672
SK-BR-3 Methotrexate 5 1250.00
inf
0.0964
 0.7954 0.8463 5.0000 0.9288
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8616
inf
0.0973
 0.6765 0.7598 5.0000 0.1162
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8831
SK-BR-3 Methotrexate 5 2500.00
inf
0.0596
 0.6525 0.6603 2.8829 0.8066
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9915
0.123
0.0605
 0.4210 0.4345 2.8603 0.3224
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9931
SK-BR-3 Methotrexate 5 5000.00
inf
0.0876
 0.5785 0.5915 4.9997 0.7731
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9971
inf
0.09
 0.5453 0.5615 4.9863 0.2413
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9969
SK-BR-3 Lapatinib 7 156.25
inf
1.7915
 0.6705 0.7164 4.9556 0.9287
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6093
inf
1.7454
 0.5464 0.6146 4.9670 0.1116
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5573
SK-BR-3 Lapatinib 7 312.50
11.5149
11.5004
 0.4845 0.0003 0.4654 0.8453
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8893
0.4776
3.7315
 -0.3556 -1.0000 0.5344 0.4092
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9319
SK-BR-3 Lapatinib 7 625.00
inf
0.2925
 0.5445 0.5671 0.6012 0.8258
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8773
0.3877
0.3617
 0.0227 0.0188 0.5495 0.3826
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9017
SK-BR-3 Lapatinib 7 1250.00
6.4508
0.0375
 0.4748 0.4874 0.7156 0.6768
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9178
0.0419
0.0394
 0.0011 0.0210 0.7083 0.6120
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.917
SK-BR-3 Lapatinib 7 2500.00
inf
0.0308
 0.5106 0.5519 1.3185 0.7050
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9765
0.0363
0.0306
 0.0161 0.0987 1.3036 0.5939
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9771
SK-BR-3 Lapatinib 7 5000.00
inf
0.0335
 0.6208 0.6324 0.9916 0.7617
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9897
inf
0.0365
 0.5197 0.5358 0.9982 0.2966
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9896
SK-BR-3 Erlotinib 7 156.25
inf
inf
 0.8034 0.8034 0.0000 0.9912
flat fit: x = Einf
0.366
inf
inf
 0.7333 0.7333 0.0000 0.0222
flat fit: x = Einf
0.428
SK-BR-3 Erlotinib 7 312.50
inf
0.1836
 0.6741 0.8258 4.9989 0.9040
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5634
0.4648
0.1724
 0.1280 0.4965 5.0000 0.2933
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5936
SK-BR-3 Erlotinib 7 625.00
inf
1.9708
 0.6487 0.6693 1.7897 0.9199
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9382
3.1402
1.937
 0.2374 0.2762 1.6638 0.1933
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.962
SK-BR-3 Erlotinib 7 1250.00
14.6718
4.2815
 0.4858 0.3990 1.2985 0.8919
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9774
3.6118
4.4969
 0.0244 -0.1591 1.2603 0.2111
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9839
SK-BR-3 Erlotinib 7 2500.00
inf
3.7065
 0.5507 0.5509 4.9204 0.9265
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9891
3.8689
3.7009
 0.0970 0.0974 4.8775 0.1539
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.992